Install SRA-Tools: First need to download prereq package https://github.com/ncbi/ncbi-vdb. Unzip package and then run: configure --prefix=/home/.hub-local make make install Then Download the SRA-Tools: https://github.com/ncbi/sra-tools Unzip pacakge and then run: ./configure --prefix=/home/.hub_local --with-ncbi-vdb=/home/.hub_local make make install That's it.